Novel rock kinase inhibitors
The present invention relates to new kinase inhibitors, more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in...
View ArticlePharmaceutical compositions
This invention provides a pharmaceutical composition comprising a eutectic composition of two pharmacologically active ingredients for delivery to the lung by inhalation. This invention also provides...
View ArticlePhenyl derivative
wherein all the symbols have the same meanings as described in the specification, has two cyclic groups, particularly phenoxy groups at specific substitution positions and thus has high human S1P2...
View ArticleMethods and compositions for treating respiratory conditions using platelet...
Described herein are methods and compositions for the treatment of respiratory diseases such as, for example, exercise induced pulmonary hemorrhage. The methods include the use of compositions...
View ArticleRespiratory disease treatment
A pharmaceutical composition adapted for pulmonary administration by inhalation is described, wherein the composition comprises a glitazone and one or more pharmaceutically acceptable carriers and/or...
View ArticleNovel human genes relating to respiratory diseases and obesity
This invention relates to isolated nucleic acids comprising genes of human chromosome 12q23-qter and the proteins encoded by these genes. Expression vectors and host cells containing such genes or...
View ArticleNon-chemotherapeutic antibiotic treatment for infections in cattle
Compositions and methods for treating and/or preventing bacterial infections in animals such as bovines are provided. The compositions and methods utilize the predatory bacterium Bdellovibrio...
View ArticleSubstituted 2-aza-bicyclo[2.2.2]octane-3-carboxylic acid...
and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with...
View ArticleSubstituted bicyclic 1-carboxylic-acid (benzyl-cyano-methyl)-amides...
and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with...
View ArticleSubstituted 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid...
and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with...
View ArticleSubstituted 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid...
and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with...
View ArticleMethod for treating inflammation
A method for treating IL-20 induced inflammation. An antagonist to IL-20 is administered to treat inflammation and associated diseases. The antagonist can be an antibody that binds to IL-20 or its...
View ArticleTreatment of inflammatory respiratory disease using biological solutions
Methods and therapeutic compositions for treating respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and devices for administering the therapeutic compositions. Methods for...
View ArticleMethods and compositions for the treatment of metabolic syndrome, obstructive...
Compositions comprising IGFBP-3 receptor agonists and methods for the treatment of metabolic syndrome, obstructive respiratory disorders, obstructive or inflammatory respiratory disease, cancers and...
View ArticleCombinations of medicaments for the treatment of respiratory diseases
wherein the molar ratio of the compound of formula 1 to the active substance 2 is 1:10 to 12:1. (b) another active substance 2, or an enantiomer, mixture of enantiomers, or racemate thereof, or an...
View ArticleComposition for inhalation
The invention relates to a formulation comprising formoterol and budesonide for use in the treatment of respiratory diseases. The composition further contains HFA 227, PVP and PEG, preferably PVP K25...
View ArticleCombinations comprising antimuscarinic agents and beta-adrenergic agonists
Combinations comprising (a) a β2 agonist and (b) an antagonist of M3 muscarinic receptors which is 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane, in the...
View ArticleNovel compounds and pharmaceutical compositions thereof for the treatment of...
Wherein R1a, R1b, R2, R4, R5, R6a, R6b, R7, R8, W, X, Cy, and the subscript a are as defined herein. The present invention relates to compounds inhibiting autotaxin (NPP2 or ENPP2), methods for their...
View Article5-oxo-ete receptor antagonist compounds
The present invention relates to novel pharmaceutically-useful compounds which are antagonists of the 5-oxo-ETE receptors, such as the OXE receptor. These compounds have use as therapeutic and/or...
View ArticleAprepitant l-proline solvates - compositions and cocrystals
Aprepitant L-proline solvate compositions and aprepitant L-proline solvate cocrystals are disclosed as well as pharmaceutical compositions containing them. The compositions and cocrystals of the...
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