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Novel rock kinase inhibitors

The present invention relates to new kinase inhibitors, more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in...

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Pharmaceutical compositions

This invention provides a pharmaceutical composition comprising a eutectic composition of two pharmacologically active ingredients for delivery to the lung by inhalation. This invention also provides...

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Phenyl derivative

wherein all the symbols have the same meanings as described in the specification, has two cyclic groups, particularly phenoxy groups at specific substitution positions and thus has high human S1P2...

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Methods and compositions for treating respiratory conditions using platelet...

Described herein are methods and compositions for the treatment of respiratory diseases such as, for example, exercise induced pulmonary hemorrhage. The methods include the use of compositions...

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Respiratory disease treatment

A pharmaceutical composition adapted for pulmonary administration by inhalation is described, wherein the composition comprises a glitazone and one or more pharmaceutically acceptable carriers and/or...

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Novel human genes relating to respiratory diseases and obesity

This invention relates to isolated nucleic acids comprising genes of human chromosome 12q23-qter and the proteins encoded by these genes. Expression vectors and host cells containing such genes or...

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Non-chemotherapeutic antibiotic treatment for infections in cattle

Compositions and methods for treating and/or preventing bacterial infections in animals such as bovines are provided. The compositions and methods utilize the predatory bacterium Bdellovibrio...

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Substituted 2-aza-bicyclo[2.2.2]octane-3-carboxylic acid...

and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with...

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Substituted bicyclic 1-carboxylic-acid (benzyl-cyano-methyl)-amides...

and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with...

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Substituted 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid...

and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with...

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Substituted 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid...

and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with...

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Method for treating inflammation

A method for treating IL-20 induced inflammation. An antagonist to IL-20 is administered to treat inflammation and associated diseases. The antagonist can be an antibody that binds to IL-20 or its...

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Treatment of inflammatory respiratory disease using biological solutions

Methods and therapeutic compositions for treating respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and devices for administering the therapeutic compositions. Methods for...

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Methods and compositions for the treatment of metabolic syndrome, obstructive...

Compositions comprising IGFBP-3 receptor agonists and methods for the treatment of metabolic syndrome, obstructive respiratory disorders, obstructive or inflammatory respiratory disease, cancers and...

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Combinations of medicaments for the treatment of respiratory diseases

wherein the molar ratio of the compound of formula 1 to the active substance 2 is 1:10 to 12:1. (b) another active substance 2, or an enantiomer, mixture of enantiomers, or racemate thereof, or an...

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Composition for inhalation

The invention relates to a formulation comprising formoterol and budesonide for use in the treatment of respiratory diseases. The composition further contains HFA 227, PVP and PEG, preferably PVP K25...

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Combinations comprising antimuscarinic agents and beta-adrenergic agonists

Combinations comprising (a) a β2 agonist and (b) an antagonist of M3 muscarinic receptors which is 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane, in the...

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Novel compounds and pharmaceutical compositions thereof for the treatment of...

Wherein R1a, R1b, R2, R4, R5, R6a, R6b, R7, R8, W, X, Cy, and the subscript a are as defined herein. The present invention relates to compounds inhibiting autotaxin (NPP2 or ENPP2), methods for their...

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5-oxo-ete receptor antagonist compounds

The present invention relates to novel pharmaceutically-useful compounds which are antagonists of the 5-oxo-ETE receptors, such as the OXE receptor. These compounds have use as therapeutic and/or...

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Aprepitant l-proline solvates - compositions and cocrystals

Aprepitant L-proline solvate compositions and aprepitant L-proline solvate cocrystals are disclosed as well as pharmaceutical compositions containing them. The compositions and cocrystals of the...

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