Rtp801l sirna compounds and methods of use thereof
The invention provides chemically modified siRNA oligonucleotides that target RTP801L, compositions comprising same and to the use of such molecules to treat, inter alia, respiratory diseases...
View ArticleNovel soft rock inhibitors
In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual...
View ArticleProbiotics for use in reducing the incidence and duration of illness
The present invention provides probiotic compositions suitable for reducing the incidence and duration of human illness. In particular, the present invention provides methods and compositions suitable...
View ArticleBiphenylcarboxamides as rock kinase inhibitors
The present invention relates to new kinase inhibitors, more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in...
View ArticleNovel compounds and compositions for treatment of breathing control disorders...
The present invention includes compounds, and compositions comprising the same, that are useful in the treatment of breathing control diseases or disorders in a subject in need thereof. The present...
View ArticleMethod of using substituted 2-aza-bicyclo[2.2.2]octane-3-carboxylic acid...
and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with...
View ArticleNovel ep4 agonist
wherein R1 and R2 are each independently a hydrogen atom or a straight chain alkyl group having a carbon number of 1-3, R3 is a hydrogen atom, an alkyl group having a carbon number of 1-4, an...
View ArticleCombination pharmaceutical composition and methods of treating diseases or...
The present invention is concerned with a combination pharmaceutical composition comprising a) an activated-potentiated form of an antibody to bradykinin, b) an activated-potentiated form of an...
View ArticleInhalation of nitric oxide for treating respiratory diseases
A method of treating a human subject which is effected by intermittent inhalation of gaseous nitric oxide at a concentration of at least 160 ppm is disclosed. The method can be utilized for treating a...
View ArticleCompounds and methods for inhibiting cif virulence factor
The present invention is a screening assay for identifying inhibitors of Pseudomonas aeruginosa CFTR Inhibitory Factor as well as compounds identified by the screening assay for use in compositions...
View ArticleBi-aromatic and tri-aromatic compounds as nadph oxidase 2 (nox2) inhibitors
Bi- and tri-aromatic compounds of the formula (I) wherein R1 to RIO and X are as defined, are Nox2 inhibitors that are useful as medicaments for the treatment of a disease or condition selected from:...
View ArticleNovel pyrazine amide compounds
wherein R1, R2, R3, R5, R4, R5, R6 and X− have the meanings as indicated in the specification, to their use as a medicament, to their use in the treatment of a disease selected from among respiratory...
View ArticleInhalation of nitric oxide for treating respiratory diseases
A method of treating a human subject which is effected by intermittent inhalation of gaseous nitric oxide at a concentration of at least 160 ppm is disclosed. The method can be utilized for treating a...
View ArticleMethods of using diaminopyrimidine p2x3 and p2x 2/3 receptor modulators for...
or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are as defined herein. Methods for treating cough, chronic cough and urges to cough associated with respiratory diseases with a P2X3...
View ArticleNovel polymorphic crystal forms of...
The present invention is directed to novel polymorphic crystal forms of a 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, heminapadisylate. The...
View ArticleMaterials and methods for respiratory disease control in canines
The subject invention pertains to isolated influenza virus that is capable of infecting canids and causing respiratory disease in the canid. The subject invention also pertains to compositions and...
View ArticleGenerating a flow-volume loop for respiratory function assessment
What is disclosed is a system and method for generating a flow-volume loop for respiratory function assessment of a subject of interest in a non-contact, remote sensing environment. In one embodiment,...
View ArticleSystems and methods for detecting infectious diseases
Systems, methods, and devices for detecting infections in a clinical sample are provided. Small-volume clinical samples obtained at a point-of-service (POS) location and may be tested at the POS...
View ArticleSystems and methods for detecting infectious diseases
Systems, methods, and devices for detecting infections in a clinical sample are provided. Small-volume clinical samples obtained at a point-of-service (POS) location and may be tested at the POS...
View ArticleInhalation of nitric oxide for treating respiratory diseases
A method of treating a human subject which is effected by intermittent inhalation of gaseous nitric oxide at a concentration of at least 160 ppm is disclosed. The method can be utilized for treating a...
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